Journal: Translational Andrology and Urology

Article Title: Diagnostic accuracy of Raman spectroscopy for prostate cancer: a systematic review and meta-analysis

doi: 10.21037/tau-20-924

Figure Lengend Snippet: Characteristics of the five studies included in the meta-analysis

Article Snippet: Among them, five studies were selected in the final quantitative analysis by screening of the full text of the nineteen studies according to the inclusion and exclusion criteria. shows the characteristics of the 5 studies included ( 8 , 14 , 16 , 20 , 21 ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 PRISMA flowchart. table ft1 table-wrap mode="anchored" t5 caption a7 Study Country Total number of patients Total number of spectra (malignant/control) Sample type Type of Raman spectroscopy Main Raman algorithm type Spectral analysis Laser (nm) Total sensitivity (%) Total specificity (%) Crow 2003, ( 20 ) United Kingdom 27 456 (249/207) snap frozen in liquid nitrogen-stored prostate tissue by prostate biopsy (stored at −80 °C) Renishaw system 1000 PCA and LDA MATLAB (Mathwork Inc.) 832 91.6 92.8 Crow 2005, ( 16 ) United Kingdom 37 197 (77/120) snap frozen prostate tissue by TURP (stored at −80 °C) Near-infrared Raman spectroscopy PCA and LDA MATLAB 6.0 (Mathwork Inc.) 785 80 88.9 Lopes 2011, ( 8 ) Brazil N/A 105 (14/91) Snap frozen and stored in liquid nitrogen stored prostate tissue by radical prostatectomy, TURP, autopsy Table-top dispersive Raman spectrometer PCA MATLAB 7.0 (Mathwork Inc.) 830 100 100 Silveira 2014, ( 14 ) Brazil 32 152 (75/77) Snap frozen in liquid nitrogen-stored prostate tissue by surgical procedure Table-top dispersive Raman spectrometer (model Dimension P-1, Lambda solutions) Ordinary least-squares analysis MATLAB 7.0 (Mathwork Inc.) 830 73.7 75 Stone 2003, ( 21 ) United Kingdom N/A 520 (313/207) Snap frozen in liquid nitrogen-stored prostate tissue by prostate biopsy (stored at −80 °C) customized Renishaw system 1000 Raman micro-spectrometer PCA and LDA MATLAB (Mathwork Inc.) 830 93.3 92.2 Open in a separate window PCA, principal components analysis; LDA, linear discriminant analysis; TURP, transurethral resection of prostate. caption a8 Characteristics of the five studies included in the meta-analysis Among all included studies in the meta-analysis, three evaluated the diagnostic performance of RS in vitro , and only one study was conducted in vivo .

Techniques: Raman Spectroscopy